Objective  To analyzes the Chinese and English literature of anti-tumor of licorice based on CiteSpace knowledge graph, and explores the research status, research hotspots and trends.

Methods  CiteSpace 6.2.R4 software was used to visually analyze the Chinese and English literature on licorice anti-tumor from January 2002 to September 2023 included in CNKI and Web of Science, and visually analyzed the research topics such as the number of publications, authors, institutions, journals, funds, and keywords.

Results  A total of 397 Chinese articles and 172 English articles were included after screening. The analysis of the authors of Chinese and English literature shows that Zheng Qiusheng and Jung are the authors with the largest number of anti-tumor articles in Chinese and English respectively, while Beijing University of traditional Chinese Medicine and Hallym University have the largest number of articles in Chinese and English respectively, and there is relatively more cooperation among research institutions in English literature. Chinese and English keyword analysis shows that the anti-tumor research of Glycyrrhiza uralensis mainly focuses on breast cancer, licorice and its active components, molecular mechanism and so on. Cluster analysis shows that research has focused on the active ingredients and clinical applications of licorice; Traditional Chinese Medicine treatment theory and commonly used compound medicines; Experimental research and mechanism of action of licorice on anti-tumor effects; Research on the mechanism of licorice in preventing and treating nephrotoxicity and other toxic side effects caused by chemotherapy drugs.

Conclusion  The study of anti-tumor mechanism of licorice and the combination of licorice and natural products may be the focus of future research.

1.Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022 [J]. CA: A Cancer Journal for Clinicians, 2022, 72(1): 7-33. DOI: 10.3322/caac.21708.

2.连小龙, 令颖, 张尚龙, 等. 甘草有效成分抗肿瘤作用机制及联合抗肿瘤研究进展[J]. 中国实验方剂学杂志, 2022, 28(11): 238-245. [Lian XL, Ling Y, Zhang SL, et al. Anti-tumor mechanism of active ingredients of Glycyrrhizae Radix et Rhizoma and its combined use in anti-tumor treatment: a review[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2022, 28(11): 238-245.] DOI: 10.13422/j.cnki.syfjx.20220922.

3.井媛媛, 王连心, 李敬华, 等. 基于文献计量的知识图谱在中医药领域中的应用分析[J]. 世界科学技术-中医药现代化, 2021, 23(10): 3779-3787. [Jing YY, Wang LX, Li JH, et al. Analysis of mapping knowledge application in the field of traditional Chinese medicine based on bibliometrics[J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2021, 23(10): 3779-3787.] DOI: 10.11842/wst.20210315001.

4.中国药典2020年版. 一部[S]. 2020: 88.

5.李葆林, 麻景梅, 田宇柔, 等. 甘草中新发现化学成分和药理作用的研究进展[J]. 中草药, 2021, 52(8): 2438-2448. [Li BL, Ma JM, Tian YR, et al. Research progress on newly discovered chemical constituents and pharmacological effects of Glycyrrhizae Radix et Rhizoma[J]. Chinese Traditional and Herbal Drugs, 2021, 52(8): 2438-2448.] DOI: 10.7501/j.issn.0253-2670.2021. 08.029.

6.陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253. [Chen Y, Chen CM, Liu ZY, et al. The methodology function of CiteSpace mapping knowledge domains[J]. Studies in Science of Science, 2015, 33(2): 242-253.] DOI: 10.3969/j.issn.1003-2053.2015.02.009.

7.毛小文, 顾志荣, 郭燕, 等. 基于CiteSpace知识图谱的红芪研究热点与趋势分析[J]. 中国中药杂志, 2022, 47(11): 3095-3104. [Mao XW, Gu ZR, Guo Y, et al. Research hotspots and trends of Hedysari Radix: based on CiteSpace knowledge map[J]. China Journal of Chinese Materia Medica, 2022, 47(11): 3095-3104.] DOI: 10.19540/j.cnki.cjcmm.20220317.501.

8.李硕, 孙悦阳, 樊景春, 等. 基于CiteSpace的中医药治疗便秘的知识图谱可视化分析[J]. 中国实验方剂学杂志, 2023, 29(4): 167-175. [Li S, Sun YY, Fan JC, et al. Visual analysis of knowledge map of constipation treated by TCM based on CiteSpace[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(4): 167-175.] DOI: 10.13422/j.cnki.syfjx.20221712.

9.史海蛟, 丁莉莉, 杨珺涵, 等. 基于CiteSpace研究中医药治疗冠心病合并高血压可视化分析[J]. 辽宁中医药大学学报, 2022, 24(12): 63-67. [Shi HJ, Ding LL, Yang JH, et al. Visualization analysis of TCM treatment of coronary heart disease compllicated with hypertension based on citespace[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2022, 24(12): 63-67.] DOI: 10.13194/j.issn.1673-842x.2022.12.012.

10.刘亮亮, 陈姬, 张波, 等. 异甘草素与光甘草定抗肿瘤转移作用比较[J].中国实验方剂学杂志, 2013, 19(18): 245-250. [Liu LL, Chen J, Zhang B, et al. Comparison of the anti-metastasis effect of isoliquiritigenin and glabridin[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2013, 19(18): 245-250.] DOI: 10.11653/syfj2013180245.

11.冉芳, 杨帆, 杨新惠, 等. 甘草查尔酮B体外细胞毒作用研究[J]. 石河子大学学报（自然科学版）, 2013, 31(3): 355-358. [Ran F, Yang F, Yang XH, et al. Study on the in vitro cytotoxic effect of Licochalcone B[J]. Journal of Shihezi University (Natural Science), 2013, 31(3): 355-358.] DOI: 10.3969/j.issn.1007-7383.2013.03.018.

12.冉芳, 王爱华, 袁萱, 等. 甘草查尔酮B诱导小鼠黑色素瘤细胞凋亡作用[J]. 中国实验方剂学杂志, 2013, 19(9): 220-224. [Ran F, Wang AH, Yuan X, et al. Apoptosis-inducing effect of licochalcone B on mouse melanoma and its mechanism[J]. China Journal of Chinese Materia Medica, 2013, 19(9): 220-224.] DOI: 10.11653/syfj2013090220.

13.刘军花, 魏华波, 姚瑛, 等. 四种不同甘草有效成分的抗肿瘤血管新生作用[J]. 现代生物医学进展, 2010, 10(14): 2731-2734. [Liu JH, Wei HB, Yao Y, et al. Anti-tumor angiogenesis of four different active ingredients from Glycyrrhiza[J]. Progress in Modern Biomedicine, 2010, 10(14): 2731-2734.] DOI: 10.13241/j.cnki.pmb.2010. 14.011.

14.崔誉蓉, 李德芳, 鞠宝, 等. 四种甘草黄酮类化合物体外抗肿瘤作用研究[J]. 食品科技, 2010, 35(7): 88-92. [Cui YR, Li DF, Ju B, et al. Anti-tumor effects of four licoflavones in vitro[J]. Food Science and Technology, 2010, 35(7): 88-92.] DOI: 10.13684/j.cnki.spkj.2010.07.068.

15.张娜, 赵秀梅, 李冬冬, 等. 美法仑–甘草次酸复合物的合成及其体外抗肿瘤活性研究[J]. 现代药物与临床, 2016, 31(7): 929-933. [Zhang N, Zhao XM, Li DD, et al. Synthesis of melphalan-glycyrrhetinic acid complexes and their antitumor activity in vitro[J]. Drugs & Clinic, 2016, 31(7): 929-933.] DOI: 10.7501/j.issn.1674-5515.2016.07.001.

16.张娜, 崔晓燕, 赵秀梅, 等. 甘草次酸衍生物的合成及其抗肝癌活性[J]. 中国实验方剂学杂志, 2015, 21(19): 37-41. [Zhang N, Cui XY, Zhao XM, et al. Synthesis and antitumor activities of 18α-glycyrrhetinic acid derivatives[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2015, 21(19): 37-41.] DOI: 10.13422/j.cnki.syfjx.2015190037.

17.张娜, 崔晓燕, 赵秀梅, 等. 甘草次酸-苦参碱复合物的合成及其抗肿瘤活性研究[J]. 现代药物与临床, 2014, 29(11): 1199-1202. [Zhang N, Cui XY, Zhao XM, et al. Synthesis of glycyrrhetinic acid-matrine complexes and their antitumor activities[J]. Drugs & Clinic, 2014, 29(11): 1199-1202.] DOI: 10.7501/j.issn.1674-5515. 2014.11.026.

18.张宇轩, 李勃深, 范容晖, 等. 基于CiteSpace知识图谱的西红花研究现状与趋势分析[J]. 中国中药杂志, 2023, 48(12): 3394-3403. [Zhang YX, Li BS, Fan RH, et al. CiteSpace knowledge map of research status and trends of croci stigma[J]. China Journal of Chinese Materia Medica, 2023, 48(12): 3394-3403.] DOI: 10.19540/j.cnki.cjcmm.20230226.503.

19.张尚龙, 连小龙, 闫潇, 等. 中药对顺铂肝毒性的保护作用及其机制研究进展[J]. 中药药理与临床, 2023, 39(8): 125-129. [Zhang SL, Lian XL, Yan X, et al. Mechanism of Chinese medicine against cisp latin-induced hepatotoxicity: a review[J]. Pharmacology and Clinics of Chinese Materia Medica, 2023, 39(8): 125-129.] DOI: 10.13412/j.cnki.zyyl.20221108.002.