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Research progress on chemical constituents, pharmacological action and clinical application of Rubi fructus

Published on Feb. 08, 2024Total Views: 991 times Total Downloads: 508 times Download Mobile

Author: PAN Ping 1 CHEN Mengting 1 LI Aoxiang 2 CHEN Hongjang 1 LUO Yiyuan 1

Affiliation: 1. College of Chinese Medicine, Zhejiang Pharmaceutical University, Ningbo 315500, Zhejiang Province, China 2. College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China

Keywords: Rubi fructus Chemical constituents Pharmacological action Clinical research

DOI: 10.12173/j.issn.1008-049X.202211657

Reference: PAN Ping, CHEN Mengting, LI Aoxiang, CHEN Hongjang, LUO Yiyuan.Research progress on chemical constituents, pharmacological action and clinical application of Rubi fructus[J].Zhongguo Yaoshi Zazhi,2024, 27(1):155-170.DOI: 10.12173/j.issn.1008-049X.202211657.[Article in Chinese]

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Abstract

Rubi fructus mainly contains contents of flavonoids, coumarins, phenolic acids,  polysaccharides, alkaloids and trace elements. Meanwhile, it has activity effects of anti-tumor, anti-oxidation, anti-aging and anti-inflammation, and is widely used in medicine, food, health food and other fields. Research progress on chemical constituents, pharmacological action and clinical application of Rubi fructus were summarized in this paper, in order to provide the theoretical guidance for the rational use of Rubi fructus and the sustainable development of the resources.

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References

1.中国药典2020年版. 一部[S]. 2020: 399.

2.管咏梅, 屈宝华, 李慧, 等. 中药覆盆子及其成熟果实研究进展[J]. 中华中医药学刊, 2022, 41(1): 1-5. [Guan YM, Qu BH, Li H, et al. Research progress on Fupenzi (Rubus idaeus L) and its mature fruits[J]. Chinese archives of traditional Chinese medicine, 2022, 41(1): 1-5.] DOI:10.13193/j.issn.1673-7717.2023.01.001.

3.刘勇, 潘海波. 覆盆子研究进展[J]. 中国中医药现代远程教育, 2023, 21(9): 197-199. [Liu Y, Pan HB. Research progress of raspberry[J]. Chinese Medicine Modern Distance Education of China, 2023, 21(9): 197-199.] DOI: 10.3969/j.issn.1672- 2779.2023.09.069.

4.肖洪明, 祖灵博, 李石平, 等. 掌叶覆盆子化学成分的研究[J]. 中国药物化学杂志, 2011, 21(3): 220-226. [Xiao HM, Zu LB, Li SP, et al. Studies on the chemical constituents of Rubus idaeus palmatum[J]. Chinese Journal of Medicinal Chemistry, 2011, 21(3): 220-226.] DOI: 10.14142/j.cnki.cn21-1313/r.2011.03.007.

5.Yu GH, Luo ZQ, Wang WB, et al. Rubus chingii Hu: a review of the phytochemistry and pharmacology[J]. Front Pharmacol, 2019, 10: 799. DOI: 10.3389/fphar.2019.00799.

6.郭启雷. 掌叶覆盆子及羊耳菊的化学成分研究[D]. 北京: 中国协和医科大学, 2005.

7.王静宜, 余俊东, 陈悦, 等. 覆盆子的化学成分研究 [J]. 中草药, 2022, 53(13): 3897-3903. [Wang JY, Yu JD, Chen Y, et al. Chemical constituents from Rubi fructus[J]. Chinese Traditional and Herbal Drugs, 2022, 53(13): 3897-3903.] DOI: 10.7501/j.issn.0253-2670.2022.13.002.

8.Han N, Gu YH, Ye C, et al. Antithrombotic activity of fractions and components obtained from raspberry leaves (Rubus chingii)[J]. Food Chem, 2012, 132(1): 181-185. DOI: 10.1016/j.foodchem.2011.10.051.

9.师聪, 解春芝, 张建萍, 等. 覆盆子不同极性溶剂提取物的抗氧化活性比较[J]. 食品科技, 2021, 46(1): 220-224. [Shi C, Xie CZ, Zhang JP, et al. Comparison of antioxidant activity of raspberry extracts with different polar solvents[J]. Food Science and Technology, 2021, 46(1): 220-224.] DOI: 10.13684/j.cnki.spkj.2021.01.035.

10.何建明, 孙楠, 吴文丹, 等. HPLC 测定覆盆子中鞣花酸、黄酮和覆盆子苷-F5的含量[J]. 中国中药杂志, 2013, 38(24): 4351-4356. [He JM, Sun N, Wu WD, et al. Determination of ellagic acid, flavonoids and goshonosidie F5 in Rubus chingii by HPLC[J]. China Journal of Chinese Materia Medica, 2013, 38(24): 4351-4356.] DOI: 10.4268/cjcmm20132431.

11.Zhang XY, Li W, Wang J, et al. Protein tyrosine phosphatase 1B inhibitory activities of ursane-type triterpenes from chinese raspberry, fruits of Rubus chingii[J]. Chin J Nat Med, 2019, 17(1): 15-21. DOI: 10.1016/S1875-5364(19)30004-4.

12.陈丽楠. 覆盆子茎化学成分及其抗肿瘤活性研究 [D]. 南昌: 南昌大学, 2022.

13.Wan J, Wang XJ, Guo N, et al. Highly oxygenated triterpenoids and diterpenoids from Fructus rubi (Rubus chingii Hu) and their NF-kappa B inhibitory effects[J]. Molecules, 2021, 26(7): 1911-1923. DOI: 10.3390/molecules26071911.

14.Tanaka T, Kawamura K, Kitahara T, et al. Ent-labdane-type diterpene glucosides from leaves of Rubus chingii[J]. Phytochemistry, 1984, 23(3): 615-621. DOI: 10.1016/S0031-9422(00)80393-3.

15.Chou WH, Toshihiko O, Fujiko K, et al. Diterpene glycosides from leaves of Chinese Rubus chingii and fruits of R. suavissimus, and identification of the source plant of the Chinese folk medicine "fu-pen-zi"[J]. Chem Pharm Bull, 1987, 35(7): 3021-3024. DOI: 10.1248/cpb.35.3021.

16.He YQ, Jin SS, Ma ZY, et al. The antioxidant compounds isolated from the fruits of chinese wild raspberry Rubus chingii Hu[J]. Natural Product Research. 2020, 34(6): 872-875. DOI: 10.1080/14786419.2018.1504046.

17.陈丽楠, 付辉政, 王兰欣, 等. 覆盆子茎中1个新的半日花烷型二萜苷[J]. 中草药, 2022, 53(10): 2941-2948. [Chen LN, Fu HZ , Wang LX, et al. A new labdane diterpene glycoside from stems of Rubus chingii[J]. Chinese Traditional and Herbal Drugs 2022, 53(10): 2941-2948.] DOI: 10.7501/j.issn.0253-2670.2022.10.002.

18.Shu JC, Huang YZ, Cui HQ, et al. Diterpenoids from leaves of Rubus chingii[J]. Nat Prod Commun, 2016, 11(3): 375-376. DOI: 10.1177/1934578X1601100314.

19.郭卿. 覆盆子化学成分及质量标准研究[D]. 南昌: 江西中医药大学, 2015.

20.卢遇. 覆盆子中降血糖成分提取分离和主要活性成分鉴定[D].南昌: 江西师范大学, 2020.

21.Ding H. Extracts and constituents of Rubus chingii with 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity[J]. Int J Mol Sci, 2011, 12(12): 3941-3949. DOI: 10.3390/ijms 12063941.

22.Sheng JY, Wang SQ, Liu KH, et al. Rubus chingii Hu: an overview of botany, traditional uses, phytochemistry, and pharmacology[J]. Chin J Nat Med, 2020, 18(6): 401-416. DOI: 10.1016/S1875-5364(20)30048-0.

23.龚剑秋, 梁文清. 覆盆子抗骨质疏松化学组成及抗骨质疏松活性成分研究[J]. 中华中医药学刊, 2016, 34(3): 657-659. [Gong JQ, Liang WQ. Chemical and antiosteoporotic activity components from Rubus chingii Hu[J]. Chinese Archives of Traditional Chinese, 2016, 34(3): 657-659.] DOI: 10.13193/j.issn.1673-7717. 2016. 03. 044.

24.游孟涛, 李亚葵, 郭美丽. 覆盆子二氯甲烷萃取物中的化学成分[J]. 第二军医大学学报, 2009, 30(10): 1199-1202. [You MT, Li YK, Guo ML. Study on chemical constituents of methylene chloride extract of Rubus chingii[J]. Academic Journal of Second Military Medical University, 2009, 30(10): 1199-1202.] DOI: 10.3724/SP.J.1008.2009.01199.

25.朱会霞, 孙金旭, 孙浩. HPLC法分析覆盆子多糖单糖组分的研究[J]. 山东化工, 2019, 48(23): 108-110. [Zhu HX, Sun JX, Sun H. The Analyzing monosaccharide composition of polysaccharides for raspberry[J]. Shandong Chemical Industry, 2019, 48(23): 108-110.] DOI: 10.19319/j.cnki.issn.1008-021x.2019.23.043.

26.Yu Z, Liu L, Xu Y, et al. Characterization and biological activities of a novel polysaccharide isolated from raspberry (Rubus idaeus L.) fruits[J]. Carbohydrate Polymers, 2015, 132: 180-186. DOI: 10.1016/j.carbpol.2015.06.068.

27.陈奎霖, 黄达荣, 黄少杰, 等. 覆盆子活性成分及其综合利用研究进展[J]. 食品与机械, 2022, 38(9): 219-226. [Chen KL, Huang DR, Huang SJ, et al. Research progress on active components and comprehensive utilization of Rubus chingii Hu[J]. Food & Machinery, 2022, 38(9): 219-226.] DOI: 10.13652/j.spjx.1003.5788.2022.90216.

28.Bilawal A, Ishfaq M, Gantumur MA, et al. A review of the bioactive ingredients of berries and their applications in curing diseases[J]. Food Biosci, 2021, 44: 101407. https://doi.org/10.1016/j.fbio.2021.101407.

29.Hendawy O, Gomaa H, Hussein S, et al. Cold-pressed raspberry seeds oil ameliorates high-fat diet triggered nonalcoholic fatty liver disease[J]. Saudi Pharm J, 2021, 29(11): 1303-1313. DOI: 10.1016/j.jsps. 2021.09.014.

30.游孟涛. 覆盆子补肾活性成分研究[D]. 上海: 第二军医大学, 2009.

31.籍艳秋. 覆盆子的补肾活性成分研究[J]. 中国卫生标准管理, 2015, 6(19): 125-126. [Ji YQ. Research the active components from the fruits of Rubus chingii Hu on replenishing kidney[J]. China Health Standard Management, 2015, 6(19): 125-126.] DOI: 10.3969/j.issn. 1674-9316.2015.19.096.

32.Zhang TT, Lu CL, Jiang JG, et al. Bioactivities and extraction optimization of crude polysaccharides from the fruits and leaves of Rubus chingii Hu[J]. Carbohydr Polym, 2015, 130: 307-315. https://doi.org/10.1016/j.carbpol.2015.05.012.

33.牛付阁, 王纪平, 王芳, 等. 覆盆子糖蛋白粗提物体内抗氧化作用研究[J]. 食品工业科技, 2010, 31(12): 134-136. [Niu FG, Wang JP, Wang F, et al. Study on antioxidation effect in vivo of glycoprotein from extract of Rubus chingii Hu[J]. Science and Technology of Food Industry, 2010, 31(12): 134-136.] DOI: 10.13386/j.issn1002-0306.2010.12.106.

34.刘明学, 牛靖娥, 苏忠伟, 等. 覆盆子多糖提取、结构分析及自由基清除作用研究[J]. 食品科技, 2009, 34(7): 163-167. [Liu MX, Niu JE, Su ZW, et al. Extraction, structure and free radicals scavenging activities of polysaccharides from Raspberry (Rubus chingii Hu)[J]. Food Science and Technology, 2009, 34(7): 163-7.] DOI: 10.13684/j.cnki.spkj.2009.07.058.

35.朱会霞. 覆盆子黄酮抗氧化活性研究[J]. 现代食品科技, 2012, 28(10): 1302-5. [Zhu HX. Study on the antioxidant activity of Raspberry flavones[J]. Modern Food Science and Technology, 2012, 28(10): 1302-1305.] DOI: 10.13982/j.mfst.1673-9078.2012.10.027.

36.王亚萍. 覆盆子糖蛋白GP3抗衰老活性及其对Klotho 基因表达的调控研究[D]. 郑州: 郑州大学, 2018.

37.亓婷婷. 覆盆子总糖蛋白抗衰老活性及其分离、纯化研究[D]. 郑州: 郑州大学, 2016.

38.蔡妙婷, 刘雯, 袁源见, 等. 覆盆子中几种黄酮类成分活性研究进展[J]. 实用中西医结合临床, 2020, 20(4): 179-182. [Cai MT, Liu W, Yuan YJ, et al. Research progress on the activity of several flavonoids in Rubus chingii[J]. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine, 2020, 20(4): 179-182.] DOI: 10.13638/j.issn.1671-4040.2020.04.092.

39.刘刚, 李巧玲, 陶妍钰, 等. 覆盆子鞣质对大鼠肝微粒体代谢酶活性的影响[J]. 中华中医药学刊, 2021, 39(1): 8-10. [Liu G, Li QL, Tao YY, et al. Effects of tannins extracted from Fupenzi (Rubus chingii Hu) on activity of hepatic micosomal enzymes in rats[J]. Chinese archives of Traditional Chinese Medicine, 2021, 39(1): 8-10.] DOI: 10.13193/j.issn.1673-7717.2021.01.003.

40.季宇彬, 包晓威, 单宇, 等. 覆盆子提取物对ConA 致小鼠急性肝损伤的保护作用研究[J]. 中国中药杂志, 2019, 44(4): 774-780. [Ji YB, Bao XW, Shan Y, et al. Protective effect of raspberry extract on ConA-induced acute liver injuryin mice[J]. China Journal of Chinese Materia Medica, 2019, 44(4): 774-780.] DOI: 10.19540/j.cnki.cjcmm.20181101.005.  

41.Ke HH, Bao T, Chen W. Polysaccharide from Rubus chingii Hu affords protection against palmitic acid-induced lipotoxicity in human hepatocytes[J]. Int J Biol Macromol, 2019, 133: 1063-1071. DOI: 10.1016/j.ijbiomac.2019.04.176.

42.苏雪慧. 覆盆子乙醇提取物对血管舒张功能及血流动力学的影响[D]. 济南: 泰山医学院, 2013.

43.樊柏林, 龚晨睿, 孙凡中, 等. 湖北掌叶覆盆子叶降血脂作用的动物实验和人群研究[J]. 食品科学, 2007, 28(11): 526-529. [Fan BL, Gong CR, Sun FZ, et al. Effects of Hubei Rubus chingii Hu leaf on serum lipid metabolism in hyperlipidemia rats and human adults[J]. Food Science, 2007, 28(11): 526-529.] DOI: 10.3321/j.issn:1002-6630.2007.11.127.

44.谢欣梅, 庞晓斌, 李晓婷. 覆盆子酮对糖尿病模型小鼠的降血糖作用及其机制研究[J]. 中国药学杂志, 2012, 47(23): 1899-1904. [Xie XM, Pang  XB, Li XT. Hypoglycemic Effect and mechanism of Raspberry ketone on diabetic model mice[J]. Chinese Pharmaceutical Journal, 2012, 47(23): 1899-1904.] DOI: CNKI:SUN:ZGYX.0.2012-23-009.

45.胡云龙. 覆盆子提取物对人肝癌SMMC-7721细胞抑制作用的研究[D]. 济南: 山东中医药大学, 2014.

46.张乃丹. 覆盆子多酚提取工艺及不同溶剂提取物抗氧化抑菌活性[D]. 杭州: 浙江农林大学, 2013.

47.Zhang TT, Liu YJ, Yang L, et al. Extraction of antioxidant and antiproliferative ingredients from fruits of Rubus chingii Hu by active tracking guidance[J]. Medchemcomm, 2017, 8(8): 1673-1680. DOI: 10.1039/C7MD00240H.

48.Zhong R, Guo Q, Zhou G, et al. Three new labdane-type diterpene glycosides from fruits of Rubus chingii and their cytotoxi activities against five humor cell lines[J]. Fitoterapia, 2015, 102: 23-26. DOI: 10.1016/j.fitote.2015. 01.007.

49.周丰宝, 杜翠翠, 王圆明. 覆盆子种子汤治疗不育症 69例[J]. 山东中医杂志, 2014, 33(6): 452-453. [Zhou FB, Du CC, Wang YM. Rubus idaeus seed decoction in the treatment of 69 cases of infertility[J]. Shandong Journal of Traditional Chinese Medicine, 2014, 33(6): 452-453.] DOI: 10.16295/j.cnki.0257-358x.2014.06.015.

50.李立煌. 中医治疗男性不育症规律的探讨[D]. 福州: 福建中医药大学, 2013.

51.王勇. 八仙种玉汤加减治疗男性不育症临床疗效观察[J]. 山西职工医学院学报, 1999, 9(2): 28-29. [Wang Y. Clinical observation on the treatment of male infertility with modified Baxian Zhongyu decoction[J]. Joumal of Shanxi Medical College of Continuing Education, 1999, 9(2): 28-29.] DOI: CNKI:SUN:SXZG.0.1999-02-019.

52.李浩, 俞旭君, 阳方, 等. 五子衍宗丸治疗男性不育症64例临床研究[J]. 中国性科学, 2020, 29(10): 123-126. [Li H, Yu XJ, Yang F, et al. Clinical investigation on male infertility treated with Wuzi Yanzong pill: 64 cases[J]. Chinese Journal of Human Sexuality, 2020, 29(10): 123-126.] DOI: 10.3969/j.issn.1672-1993.202.10.034.

53.李伟明, 徐英. 张大宁治疗肾性蛋白尿用药规律分析[J]. 河南中医, 2018, 38(1): 137-141. [Li WM, Xu Y. Analysis of Zhang Daning's medication rule in the treatment of renal Proteinuria[J]. Henan Traditional Chinese Medicine, 2018, 38(1): 137-141.] DOI: 10.16367/j.issn.1003-5028.2018.01.0036.

54.吕翠岩, 贾晓蕾, 李倩, 等. 参芪地黄汤化裁方对Ⅳ期DN尿蛋白及临床进展的影响[J]. 中医学报, 2020, 35(11): 2433-2438.[Lyu CY, Jia XL, Li Q, et al. Effect of modified Shenqi Dihuang decoction on urinary protein and clinical progress of stage IV DN[J]. China Journal of Chinese Medicine, 2020, 35(11): 2433-2438.] DOI: 10. 16368/j.issn.1674-8999.2020.11.539.

55.何少增. 鸡蛋覆盆子散治疗遗尿[J]. 山西中医, 1995, (4): 36. [He SZ. Eggs and Rubus idaeus powder for treating enuresis[J]. Shanxi Journal of Traditional Chinese Medicine, 1995, (4): 36.] http://www.cnki.com.cn/Article/CJFDTotal-SHIX504.027.htm.

56.郭奇裕. 三子止遗汤治疗遗尿症[J]. 新中医, 2002, 34(2): 16. [Guo QY. Treatment of enuresis with Sanzi Zhiyi Tang[J]. New Chinese Medicine, 2002, 34(2): 16.] DOI: 10.13457/j.cnki.jncm.2002.02.007.

57.曲彬彬. 补肾化瘀法联合达英-35治疗多囊卵巢综合征30例临床疗效分析[J]. 中国现代医生, 2017, 55(5): 116-118. [Qu BB. Clinical curative analysis of 30 cases of tonifying kidney and removing the blood stasis combined with Diane-35 in the treatment of polycystic ovary syndrome[J]. China Modern Doctor, 2017, 55(5): 116-118.] DOI: CNKI:SUN:ZDYS.0.2017-05-035.

58.刘红根, 孙振高, 刘继鹏, 等. 卵巢早衰的从厥阴病论治[J]. 时珍国医国药, 2018, 29(8): 1940-1943. [Liu HG, Sun ZG, Liu JP, et al. Treatment of premature ovarian failure on Jue Yin disease[J]. Lishizhen Medicine and Materia Medica Research, 2018, 29(8): 1940-1943.] DOI: 10.3969/j.issn.1008-0805.2018.08.051.

59.金红花, 夏阳. 益精补冲汤治疗卵巢储备功能低下55例临床观察[J]. 中医杂志, 2008, (9): 790-792. [Jin HH, Xia Y. Clinical observation on the 55 cases of poor ovary reserve function treated by Yijing Buchong decoction[J]. Journal of Traditional Chinese Medicine, 2008, (9): 790-792.] DOI: 10.13288/j.11-2166/r.2008.09.010.

60.杨蓉, 陈莹. 陈莹补肾填精治疗卵巢早衰及卵巢储备功能低下[J]. 实用中医内科杂志, 2015,29(1): 10-12. [Yang R, Chen Y. Professor CHEN Ying treats premature ovarian failure and decline in ovarian reserve by tonifying the kindey essence[J]. Journal of Practical Traditional Chinese Internal Medicine, 2015, 29(1): 10-12.] DOI: 10.13729/j.issn.1671-7813.2015.01.05.

61.毕焕英. 补肾养肝法治疗黄体功能不健性不孕临床观察[J]. 北京中医药大学学报(中医临床版), 2003, 10(1): 11-12. [Bi HY. Clinical observation on treatment of infertility caused by inefficient corpus luteum by the therapy of invigorating kidney and liver[J]. Journal of Beijing University of TCM (Clinical Medicine), 2003, 10(1): 11-12.] DOI: 10.3969/j.issn.1672-2205.2003.01.007.

62.秦正光,贺叔梅. 妇炎消糖浆临床188例疗效观察[J]. 中成药, 1994, (3): 30. [Qin ZG, He SM. Clinical observation on 188 cases of Fuyanxiao syrup[J]. Chinese Traditional Patent Medicine, 1994, (3): 30.] http://www.cnki.com.cn/Article/CJFDTotal-ZCYA403.020.htm.

63.段凌燕, 陈思思, 李永平, 等. 基于"补五脏之阴"刍议覆盆子在妇科杂病中的应用[J]. 实用中医内科杂志, 2020, 34(5): 24-27. [Duan LY, Chen SS, Li YP, et al. On the application of Fupenzi (Raspberry) in gynecology miscellaneous diseases[J]. Journal of Practical Traditional Chinese Internal Medicine, 2020, 34(5): 24-27.] DOI: 10.13729/j.issn.1671-7813.z20191172.

64.高平义, 华满堂, 吕鸿彬, 等. 纯中草药擦剂治疗痤疮42例[J]. 西北国防医学杂志, 1997, (1): 59. [Gao PY, Hua MT, Lu HB, et al. 42 cases of acne treatment with pure Chinese herbal rubbing[J]. Medical Journal of National Defending Forces in Northwest China, 1997, (1): 59.] DOI: 10.16021/j.cnki.1007-8622.1997.01.048.

65.亓贯和, 王静, 李业永. 覆盆子浆对原发性肝癌细胞影响的临床研究[J]. 山西中医学院学报, 2010, 11(4): 22-24. [Qi GH, Wang J, Li YY. Clinical study on the effect of Rubus idaeus Pulp on primary liver cancer cells[J]. Journal of Shanxi University of Chinese Medicine, 2010, 11(4): 22-24.] DOI: 10.3969/j.issn.1671-0258.2010.04.010.

66.薛均来. 覆盆子抑制基质金属蛋白酶活性与抗肿瘤机理的实验研究[D]. 长春: 吉林大学, 2010.

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