Research on the sources, structures and identification technology of glucosamine drugs

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Author: DAN Xiaomeng ^1, ² LIU Xiaofeng ^1, ²  GUO Jianghong ^1, ²  JIANG Hong ^1, ²

Affiliation: 1. Hubei Institute for Drug Control, Wuhan 430073, China 2. NMPA Key Laboratory for Quality Control of Blood Products, Wuhan 430073, China

Keywords: Hydrochloric glucosamine Sulfate glucosamine Source Structure Identification

DOI: 10.12173/j.issn.1008-049X.202311269

Reference: DAN Xiaomeng, LIU Xiaofeng, GUO Jianghong, JIANG Hong.Research on the sources, structures and identification technology of glucosamine drugs[J].Zhongguo Yaoshi Zazhi,2024, 24(4):551-556.DOI: 10.12173/j.issn.1008-049X.202311269.[Article in Chinese]  Copied

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Abstract

Objective To sort out and summarize the researches of source, structures and identification technologies of glucosamine drugs, and provide a reference for the development and research of this kind of drugs.

Methods The sources of glucosamine drugs was identified by stable isotope ratio test, and the crystal structures of glucosamine drugs was identified by X-ray powder diffraction.

Results When the carbon isotope ratio was between -11‰ and -13‰, the source of glucosamine was from microbial fermentation. When the carbon isotope ratio was between -17‰ and -24‰, the source of glucosamine was from microbial animals. The 2θ angles of the strongest diffraction peak of hydrochloric glucosamine were 16.525°, 12.360° and 17.330°, the 2θ angles of the strongest diffraction peak of sodium sulfate were 32.124° and 19.035, the 2θ angle of the strongest diffraction peak of the glucosamine sulfate potassium chloride/sodium was 27.036°, and the 2θ angle of the strongest diffraction peak of the physical mixture of glucosamine hydrochloride and chloride/sodium sulfate (2 ∶ 1) was 12.391°. Through X-ray powder diffraction technology, the glucosamine sulfate potassium chloride/sodium eutectic complex salt and the physical mixture of glucosamine hydrochloride and chloride/sodium sulfate.can be distinguished.

Conclusion The research can effectively identify the sources and structures of glucosamine drugs, which is simple, accurate and reliable, and provides technical support for the supervision and management of glucosamine drugs.

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References

1.纪立伟, 傅得兴. 氨基葡萄糖的药理作用及安全性 [J]. 中国药学杂志, 2007, 42(19): 1513-1516. [Ji LW, Fu DX. Pharmacology and safety of glucosamine[J]. Chinese Pharmaceutical Journal, 2007, 42(19): 1513-1516.] DOI: 10.3321/j.issn:1001-2494.2007.19.022.

2.韩丽华. 盐酸氨基葡萄糖胶囊治疗骨关节炎的现状及进展研究[J]. 中国现代药物应用, 2020, 14(8): 232-233. [Han LH. The status and research progress of glucosamine hydrochloride capsules in the treatment of osteoarthritis[J]. Chinese Journal of Modern Drug Application, 2020, 14(8): 232-233.] DOI: 10.14164/j.cnki.cn11-5581/r.2020.08.110.

3.但晓梦, 谢育媛, 郭江红, 等. 盐酸氨基葡萄糖颗粒有关物质方法的建立与验证[J]. 中国药师, 2022, 25(7): 1282-1287. [Dan XM, Xie YY, Guo JH, et al. Establishment and Validation of the Determination Method for the Related Substance in Glucosamine Hydrochloride Granules[J]. China Pharmacist, 2022, 25(7): 1282-1287.] DOI: 10.19962/j.cnki.issn1008-049X.2022.07.034.

4.European Food Safety Authority. Scientific opinion on the substantiation of a health claim related to glucosamine and maintenance of joints pursuant to Article 13(5) of Regulation (EC) No 1924/2006[J]. EFSA J, 2011, 9(12): n/a-n/a. DOI: 10.2903/j.efsa.2011.2476.

5.Mccarty MF, O'Keefe JH, Dinicolantonio J. Glucosamine for the treatment of osteoarthritis: the time has come for higher-dose trials[J]. J Diet Suppl, 2019, 16(2): 179-192. DOI: 10.1080/19390211.2018.1448920.

6.同位素地质样品分析方法总则及一般规定[S]. DZ/T 0184.1-1997. 1997.

7.地质样品有机地球化学分析方法[S]. GB/T 18340.2-2010. 2010.

8.张淼. 硫酸氨基葡萄糖制剂的质量研究[D]. 杭州: 浙江工业大学, 2019.

9.迟海林, 李菲菲, 张李伟, 等. 氨基葡萄糖类物质在保健食品中的应用及研究进展[J]. 食品工业科技, 2023 44(8): 437-445. [Chi HL, Li FF, Zhang LW, et al. Application and research progress of glucosamine in health food[J]. Science and Technology of Food Industry, 2023, 44(8): 437-445. ] DOI: 10.13386/j.issn1002-0306.2022050211.

10.李旭, 李康, 汪俊卿, 等. 氨基葡萄糖微生物合成研究进展[J]. 齐鲁工业大学学报, 2021, 35(1): 19-22. [Li X, Li K, Wang JQ, et al. Research progress of glucosamine microbial synthesis[J]. Journal of Shandong Institute of Light Industry (Natural Science Edition), 2021, 35(1): 19-22.] DOI: 10.16442/j.cnki.qlgydxxb.2021.01.004.

11.孙丽. 虾头制备盐酸氨基葡萄糖的优化研究[J]. 福建分析测试, 2018, 27(3): 15-19. [Sun L. Optimization research of preparation of glucosamine hydrochloride from shrimp head[J]. Fujian Analysis & Testing, 2018, 27(3): 15-19.] DOI: 10.3969/j.issn.1009-8143.2018.03.04.

12.Zhang HK, Lu YT, Wang YH, et al. D-glucosamine production from chitosan hydrolyzation over a glucose-derived solid acid catalyst[J]. RSC Adv, 2018, 8(10): 5608-5613. DOI: 10.1039/c7ra12490b.

13.张健. 一种硫酸氨基葡萄糖氯化钠复盐的合成方法: 中国专利, 110903330A[P]. 2020-03-24.

14.王升, 李丕武, 刘佃磊, 等. 利用发酵法生产氨基葡萄糖的研究进展[J]. 生物技术通报, 2014, (1): 68-74. [Wang S, Li PW, Liu DL, et al. Review on research progresses in the fermentation methods to produce glucosamine[J]. Biotechnology Bulletin, 2014, (1): 68-74.] DOI: 10.13560/j.cnki.biotech.bull.1985.2014.01.010.

15.刘佃磊, 李丕武, 李瑞瑞, 等. 高产氨基葡萄糖基因工程菌的研究进展[J]. 生物技术通报, 2014(3): 36-41. [Liu DL, Li PW, Li RR, et al. Research advance of the construction of gene engineering strains for glucosamine[J]. Biotechnology Bulletin, 2014(3): 36-41.] DOI: 10.13560/j.cnki.biotech.bull.1985.2014.03.005.

16.Yeon JC，Eun JK，Zhe P, et al. Purification and characterization of chitosanase from Bacillus sp. strain KCTC 0377BP and its application for the production of chitosan oligosaccharides [J]. Appl Envir Microbiol, 2004, 70(8): 4522-4531. DOI: 10.1128/AEM.70.8.4522-4531.2004.

17.但晓梦. 氨基葡萄糖类药物质量控制的研究[D]. 武汉: 华中科技大学, 2012.